Cryo-electron tomography of NLRP3-activated ASC complexes reveals organelle co-localization
Abstract NLRP3 induces caspase-1-dependent pyroptotic cell death to drive inflammation.Aberrant activity of NLRP3 occurs in many animed blue lotion topical spray human diseases.NLRP3 activation induces ASC polymerization into a single, micron-scale perinuclear punctum.Higher resolution imaging of this signaling platform is needed to understand how